Prostaglandin analog mechanisms are not effective in refractory chronic cluster headache.

Abstract

Prostaglandin E analogs have been shown to be effective in the treatment of refractory trigeminal neuralgia in patients with multiple sclerosis. Prostaglandin E inhibits the functions of T lymphocytes which are involved in the pathophysiology of cluster headache. Therefore, a double-blind, placebo-controlled, crossover study on the efficacy of misoprostol in chronic refractory cluster headache was performed. Eight patients were treated with 600 micrograms misoprostol and with placebo for a 2-week period. No differences in attack frequency, intensity, global impression, and side effects could be detected, suggesting that prostaglandin E analogs are not effective in the treatment of chronic cluster headache.

• Authors: S Evers, H Masur, P Sörös, R Brilla, I W Husstedt
• Journal: Headache (Headache) Vol. 38 Issue 8 Pg. 618-20 (Sep 1998) ISSN: 0017-8748 [Print] United States
• PMID: 11398306 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Misoprostol

Topics

• Adult
• Chronic Disease
• Cluster Headache (drug therapy, prevention & control)
• Cross-Over Studies
• Double-Blind Method
• Humans
• Male
• Middle Aged
• Misoprostol (therapeutic use)
• Pain, Intractable (drug therapy)