Abstract | OBJECTIVE: METHODS: RESULTS: The ET level of all patients was significantly higher than that of the normal control (P < 0.001), and level of CGRP in patients was not different from normal control significantly (P > 0.05). After treatment, results showed that: (1) The ET levels and the scores of clinical symptoms of both groups decreased significantly (P < 0.01), and ST segment elevated markedly (P < 0.01) as compared with before treatment, and the changes revealed more evident in XMT group in comparison with those of the control group (P < 0.05-P < 0.01). (2) The level of CGRP was significantly increased in XMT group (P < 0.01) while unchanged in the control group (P > 0.05). CONCLUSIONS: There is severe damage of vascular endothelial cells in CHD patients. XMT could not only reduce significantly the plasma ET content, but also enhance markedly the production and release of CGRP, so it has a good anti-ischemic effect, which may be closely related with its action on improving the function of vascular endothelial cells and regulating metabolism of ET and CGRP.
|
Authors | R Qiu, J He |
Journal | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
(Zhongguo Zhong Xi Yi Jie He Za Zhi)
Vol. 18
Issue 2
Pg. 74-6
(Feb 1998)
ISSN: 1003-5370 [Print] China |
PMID | 11367648
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Capsules
- Drugs, Chinese Herbal
- Endothelins
- Calcitonin Gene-Related Peptide
|
Topics |
- Aged
- Angina Pectoris
(blood, drug therapy, pathology)
- Calcitonin Gene-Related Peptide
(blood)
- Capsules
- Drugs, Chinese Herbal
(therapeutic use)
- Endothelins
(blood)
- Endothelium, Vascular
(pathology)
- Female
- Humans
- Male
- Middle Aged
|