Botulinum toxin for treatment of spasticity in adults.

Abstract

Although a few hundred papers have been published on the treatment of adult spasticity with botulinum toxin, the number of randomized placebo-controlled double-blind studies, by comparison, is relatively small. Criteria of highest evidence classes are met by the following observations: 1) Botulinum toxin improves motor functions (ability to walk and stand in the presence of spastic equinus deformity and knee flexor spasticity, upper-extremity movements). 2) Botulinum toxin makes attendance of spastic adults easier (personal hygiene in patients presenting with severe adductor spasticity; self-care and dressing in the presence of arm spasticity). 3) Early initiation of treatment with botulinum toxin yields better results than delayed institution (hemispasticity).

• Authors: G Reichel
• Journal: Journal of neurology (J Neurol) Vol. 248 Suppl 1 Pg. 25-7 (Apr 2001) ISSN: 0340-5354 [Print] Germany
• PMID: 11357235 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Dyskinesia Agents
• Botulinum Toxins

Topics

• Activities of Daily Living
• Adult
• Animals
• Anti-Dyskinesia Agents (therapeutic use)
• Botulinum Toxins (therapeutic use)
• Humans
• Muscle Spasticity (drug therapy)
• Randomized Controlled Trials as Topic (methods)