Abstract | OBJECTIVE: MATERIALS AND METHODS: TMJ aspirates were obtained from 48 patients (48 joints) with chronic TMJ disorders and from 18 controls (18 joints). The IL-1 beta and IL-6 levels in the aspirates were determined by using an enzyme-linked immunosorbent assay and the TIMP-1 level was measured by an enzyme immunoassay. Following examinations for pain upon joint movements and X-ray and MRI observations, the IL-1 beta, IL-6, and TIMP-1 levels and frequencies of their detection were compared. RESULTS: The IL-1 beta level and frequency of detection showed no correlation with pain upon joint movements or with the X-ray and MRI findings. In the frequency of detection of IL-6, there were significant differences between control (no detection) and all chronic TMJ disorder groups that were classified by imaging diagnosis (P < 0.001). A correlation was also noted between the presence of IL-6 and pain upon joint movements. The IL-6 level was correlated with the TIMP-1 level and with pain upon joint movements. TIMP-1 level was correlated with pain upon joint movements. The TIMP-1 was present in higher level from patients with chronic TMJ disorders who exhibited osseous changes on the X-ray images. CONCLUSION: The results indicated that the IL-6 and TIMP-1 levels in the TMJ aspirates of patients with chronic TMJ disorders have been raised. The former was not detected in the TMJ aspirates of the control. These findings suggest that IL-6 and TIMP-1 might play a role in the etiology of chronic TMJ disorders, but further studies are needed to validate this.
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Authors | C Shinoda, S Takaku |
Journal | Oral diseases
(Oral Dis)
Vol. 6
Issue 6
Pg. 383-90
(Nov 2000)
ISSN: 1354-523X [Print] Denmark |
PMID | 11355271
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Interleukin-1
- Interleukin-6
- Protease Inhibitors
- Tissue Inhibitor of Metalloproteinase-1
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Topics |
- Adult
- Analysis of Variance
- Arthralgia
(diagnostic imaging, metabolism, pathology)
- Bone Resorption
(diagnostic imaging, metabolism, pathology)
- Cartilage, Articular
(diagnostic imaging, metabolism, pathology)
- Chronic Disease
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Immunoenzyme Techniques
- Interleukin-1
(analysis)
- Interleukin-6
(analysis)
- Joint Dislocations
(diagnostic imaging, metabolism, pathology)
- Magnetic Resonance Imaging
- Male
- Osteoarthritis
(diagnostic imaging, metabolism, pathology)
- Protease Inhibitors
(analysis)
- Radiography
- Range of Motion, Articular
- Statistics as Topic
- Statistics, Nonparametric
- Synovial Fluid
(metabolism)
- Temporomandibular Joint
(diagnostic imaging, metabolism, pathology)
- Temporomandibular Joint Disc
- Temporomandibular Joint Disorders
(diagnostic imaging, metabolism, pathology)
- Temporomandibular Joint Dysfunction Syndrome
(diagnostic imaging, metabolism, pathology)
- Tissue Inhibitor of Metalloproteinase-1
(analysis)
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