Severe
alcoholic hepatitis (SAH) is not simply a disease of the liver, but it also causes
infection and
multiple organ failure, and therefore carries an extremely poor prognosis. We report the successful treatment of two patients with SAH. Case 1: The patient was a 55-year-old man. He was a heavy drinker whose alcohol intake had increased for some 3 years to 1.8 L sake a day. Slight clouding of consciousness,
fever, and
jaundice were evident on his admission to our hospital. Laboratory data showed
leukocytosis with a predominance of polymorphonuclear leukocytes, and a decline in coagulability. He tested negative for various hepatitis virus markers. With the diagnosis of SAH made,
steroid pulse
therapy and
bilirubin adsorption
therapy were administered. The
jaundice improved and the
interleukin-8 (IL-8) level decreased. Continuous
intravenous infusion of urinastarine (
Miraclid) normalized the
granulocyte elastase level. Improvement was also seen in coagulability,
ascites,
icterus and consciousness. Case 2: The patient was a 49-year-old man. He was a heavy drinker whose alcohol intake had increased for 1 month.
Fever,
jaundice,
ascites, and mild disturbance of consciousness were evident at the time of admission. Examination on admission diagnosed SAH.
Bilirubin adsorption and continuous
intravenous infusion of urinastarine were initiated. As a result, circulating
IL-8 level was decreased and coagulability was improved.
Therapy for granulocytic hyperelastasemia and
hypercytokinemia supervening on SAH is a new effective approach on improvement in the disease.