Budd--Chiari syndrome and heparin-induced thrombocytopenia.

Abstract

We report on a patient suffering from Budd--Chiari disease who developed heparin-induced thrombocytopenia preoperatively. Dorsocranial liver resection and hepatoatrial anastomosis were performed with the extracorporeal circulation and perioperative anticoagulation was achieved with r-hirudin. Surprisingly, thrombus formation was observed in the venous reservoir although ACT was 590 s and aPTT 55 s. An additional bolus of hirudin and rinsing the reservoir allowed unproblematic discontinuation of the cardiopulmonary bypass.

• Authors: T Carrel, P Berdat, J Schmidli, E Gygax
• Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (Eur J Cardiothorac Surg) Vol. 19 Issue 4 Pg. 525-7 (Apr 2001) ISSN: 1010-7940 [Print] Germany
• PMID: 11306328 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticoagulants
• Fibrinolytic Agents
• Heparin

Topics

• Adult
• Anticoagulants (adverse effects)
• Budd-Chiari Syndrome (complications, surgery)
• Cardiopulmonary Bypass
• Fibrinolytic Agents (therapeutic use)
• Heparin (adverse effects)
• Hirudin Therapy
• Humans
• Male
• Monitoring, Intraoperative
• Thrombocytopenia (chemically induced)