FR198248, a new anti-influenza agent isolated from Apsergillus terreus No 13830. I. Taxomony, fermentation, isolation, physico-chemical properties and biological activities.

Abstract	A novel anti-influenza agent, FR198248, was isolated from the cultured broth of a fungal strain No.13830. The strain was identified as Aspergillus terreus from morphological characteristics. FR198248, a new type of hydroxyl benzaldehyde compound, showed antiinfluenza virus activity in Madin-Darby canine kidney (MDCK) cells in vitro. The mode of action of FR198248 against influenza virus A could be ascribed to an inhibitory effect on the stage of virus adsorption. Furthermore, FR198248 possessed potent in vivo anti-influenza activity in a murine model of respiratory tract infection.
Authors	Y Nishihara, E Tsujii, Y Yamagishi, K Sakamoto, Y Tsurumi, S Furukawa, R Ohtsu, T Kino, M Hino, M Yamashita, S Hashimoto
Journal	The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 54 Issue 2 Pg. 136-43 (Feb 2001) ISSN: 0021-8820 [Print] England
PMID	11302485 (Publication Type: Journal Article)
Chemical References	Antiviral Agents Benzofurans FR 198248
Topics	Animals Antiviral Agents Aspergillus (metabolism) Benzofurans Cell Line Cell Survival (drug effects) Chromatography, High Pressure Liquid Dogs Female Influenza A virus (drug effects) Mice Mice, Inbred BALB C Microbial Sensitivity Tests Spectrometry, Fluorescence

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