Lymphoproliferative disorders in renal transplant patients in Japan.

Abstract

Post-transplantation lymphoproliferative disorders (PT-LPD) are characterized by a clinically and morphologically heterogeneous group of lymphoid proliferation occurring after organ or bone marrow transplantation. The immunodeficient state provides a basis for lymphomagenesis probably through activation of oncogenic viruses. Twenty-four patients in whom PT-LPD developed after renal transplantation in Japan were analyzed. They received hemodialysis for 4 to 226 (median 13) months before transplantation. In situ hybridization was performed to detect Epstein-Barr virus (EBV). Polymerase chain reaction and Southern hybridization with primers in the tax and pol regions of human T-cell leukemia virus type I (HTLV-1) were performed on DNA extracted from paraffin-embedded specimens. Immunohistochemical analysis revealed that 12 cases were B-cell type, 10 cases (42%) T-cell type and 2 NK-cell type. Five of the T-cell cases were classified as adult T-cell lymphoma with proven HTLV-1 genome in the tumor and seropositivity for the virus. These cases were classified as adult T-cell lymphoma (ALT). More than 80% of B-cell, 30% of T-cell and both NK/T-cell lymphomas were EBV-positive. Co-infection of EBV and HTLV-1 was found in 2 cases with ATL. These findings showed that ATL is common among Japanese renal transplant patients, which might be due to transmission of HTLV-1 via blood transfusion during hemodialysis.

• Authors: Y Hoshida, T Li, Z Dong, Y Tomita, A Yamauchi, J Hanai, K Aozasa
• Journal: International journal of cancer (Int J Cancer) Vol. 91 Issue 6 Pg. 869-75 (Mar 15 2001) ISSN: 0020-7136 [Print] United States
• PMID: 11275994 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2001 Wiley-Liss, Inc.

Chemical References

• DNA Primers
• DNA, Viral

Topics

• Adolescent
• Adult
• DNA Primers (chemistry)
• DNA, Viral (analysis)
• Epstein-Barr Virus Infections (etiology, virology)
• Female
• HTLV-I Infections (etiology, virology)
• Herpesvirus 4, Human (genetics, isolation & purification)
• Human T-lymphotropic virus 1 (genetics, isolation & purification)
• Humans
• Immunoenzyme Techniques
• Immunophenotyping
• In Situ Hybridization
• Kidney Transplantation (adverse effects)
• Lymphoma, B-Cell (etiology, genetics)
• Lymphoma, T-Cell (etiology, genetics)
• Lymphoproliferative Disorders (etiology, virology)
• Male
• Middle Aged
• Polymerase Chain Reaction
• Renal Dialysis