Beneficial effect of combination therapy with ozagrel and pranlukast in exercise-induced asthma demonstrated by krypton-81 m ventilation scintigraphy--a case report.

Abstract

INTRODUCTION:

We evaluated the effect of combination therapy with thromboxane A2 synthesis inhibitor and leukotriene receptor antagonist in a patient with exercise-induced asthma using krypton-81 m ventilation scintigraphy.

CLINICAL PICTURE:

In a patient with exercise-induced asthma, we found exercise-induced abnormalities of respiratory function test and ventilation scintigraphy, and increases in plasma concentrations of thromboxane B2 and leukotriene C4 with exercise.

TREATMENT:

A thromboxane A2 synthesis inhibitor (ozagrel) and a leukotriene receptor antagonist (pranlukast) were prescribed.

OUTCOME:

After treatment for 2 weeks, abnormalities of respiratory function test and ventilation scintigraphy improved.

CONCLUSIONS:

The combination therapy with ozagrel and pranlukast might be useful for the relief of symptoms in patients with exercise-induced asthma, and krypton-81 m ventilation scintigraphy could be a useful tool for visible evaluation of treatment.

• Authors: N Takahashi, Y Ishibashi, Y Murakami, H Shimizu, Y Ohta, T Asanuma, H Katoh, K Sano, T Shimada
• Journal: Annals of the Academy of Medicine, Singapore (Ann Acad Med Singap) Vol. 29 Issue 6 Pg. 766-9 (Nov 2000) ISSN: 0304-4602 [Print] Singapore
• PMID: 11269987 (Publication Type: Case Reports, Journal Article)

Chemical References

• Chromones
• Enzyme Inhibitors
• Krypton Radioisotopes
• Leukotriene Antagonists
• Methacrylates
• ozagrel
• pranlukast

Topics

• Asthma, Exercise-Induced (diagnostic imaging, drug therapy)
• Chromones (administration & dosage)
• Drug Therapy, Combination
• Enzyme Inhibitors (administration & dosage)
• Female
• Follow-Up Studies
• Humans
• Krypton Radioisotopes
• Leukotriene Antagonists (administration & dosage)
• Methacrylates (administration & dosage)
• Middle Aged
• Radionuclide Imaging
• Respiratory Function Tests
• Severity of Illness Index
• Treatment Outcome