Resveratrol decreases hyperalgesia induced by carrageenan in the rat hind paw.

Abstract

The effect of resveratrol, an aryl hydrocarbon receptor (AhR) antagonist, known to inhibit inducible cyclooxygenase-2 (COX2) and its transcription were examined in a model of hyperalgesia induced by carrageenan in the rat. Pretreatment with resveratrol did not reverse swelling and edema, but reversed the hyperalgesia induced by local tissue injury provoked by carrageenan. This reversal, occurring at resveratrol concentrations as low as 2 mg/kg, lasted for at least 48 hours. The link with COX2 activity inhibition and COX2 gene transcription, as well as a potential AhR inhibitory effect, remain to be established.

• Authors: M Gentilli, J X Mazoit, H Bouaziz, D Fletcher, R F Casper, D Benhamou, J F Savouret
• Journal: Life sciences (Life Sci) Vol. 68 Issue 11 Pg. 1317-21 (Feb 02 2001) ISSN: 0024-3205 [Print] Netherlands
• PMID: 11233998 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Cyclooxygenase 2 Inhibitors
• Cyclooxygenase Inhibitors
• Isoenzymes
• Receptors, Aryl Hydrocarbon
• Stilbenes
• Carrageenan
• Cyclooxygenase 2
• Prostaglandin-Endoperoxide Synthases
• Resveratrol

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Carrageenan
• Cyclooxygenase 2
• Cyclooxygenase 2 Inhibitors
• Cyclooxygenase Inhibitors (therapeutic use)
• Edema (chemically induced)
• Foot
• Hindlimb
• Hyperalgesia (chemically induced, drug therapy)
• Isoenzymes (antagonists & inhibitors)
• Kinetics
• Male
• Pain Measurement
• Prostaglandin-Endoperoxide Synthases
• Rats
• Rats, Sprague-Dawley
• Receptors, Aryl Hydrocarbon (antagonists & inhibitors)
• Resveratrol
• Stilbenes (therapeutic use)
• Vocalization, Animal