Abstract | OBJECTIVES: STUDY DESIGN: The growth of the cells was studied after in vitro or dietary supplementation with Se in a murine model. RESULTS: Treatment of established tumors in hosts supplemented with Se with peritumoral injections of IL-2 resulted in 50% reduction of tumor size, whereas treatment of early tumors resulted in 72.4% reduction. The effect was most likely related to a combination of enhanced immune responsiveness and enhanced IL-2 receptor expression on the tumor cells. CONCLUSIONS AND SIGNIFICANCE: The data suggested that local immunotherapy with IL-2 in hosts supplemented with Se may represent an effective modality of treatment for the prevention of recurrences at the site of conventionally treated primary tumors, including tumors that do not express IL-2 receptors.
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Authors | S Thikkurissy, A Pavone, A Rega, R Bae, M Roy, H I Wishe, L Kiremidjian-Schumacher |
Journal | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
(Otolaryngol Head Neck Surg)
Vol. 124
Issue 2
Pg. 142-9
(Feb 2001)
ISSN: 0194-5998 [Print] England |
PMID | 11226946
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Interleukin-2
- Receptors, Interleukin-2
- Selenium
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Topics |
- Animals
- Carcinoma, Squamous Cell
(metabolism, pathology, therapy)
- Cell Division
(drug effects)
- In Vitro Techniques
- Interleukin-2
(therapeutic use)
- Killer Cells, Natural
(drug effects)
- Male
- Mice
- Receptors, Interleukin-2
(analysis)
- Selenium
(pharmacology)
- Tumor Cells, Cultured
(drug effects)
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