Abstract |
The chemical study of aerial parts of Lampaya hieronymi Schum. ex Moldenke yielded oleanolic acid, epi- oleanolic acid, epi- maslinic acid, 4'7-dimethoxyapigenin, p-hydroxyacetophenone, and p-hydroxyacetophenone-beta- glucoside. In searching for natural products as potential anti-inflammatory agents, all the compounds, except 4'7-dimethoxyapigenin were evaluated in vivo for their ability to inhibit acute inflammation. Our studies demonstrated that p-hydroxyacetophenone and the triterpenes produced protective effects in carrageenan induced paw edema in mouse, at 1-3 h and 3-5 h, respectively, after the injection of carrageenan. These results indicated that their effects might correlate with the release of histamine, serotonin, kinin and prostaglandins.
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Authors | M E Alvarez, A E Rotelli, L E Pelzer, J R Saad, O Giordano |
Journal | Farmaco (Societa chimica italiana : 1989)
(Farmaco)
2000 Jun-Jul
Vol. 55
Issue 6-7
Pg. 502-5
ISSN: 0014-827X [Print] France |
PMID | 11204754
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Plant Extracts
- Carrageenan
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Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, isolation & purification, pharmacology)
- Carrageenan
- Edema
(chemically induced, prevention & control)
- Female
- Injections, Intraperitoneal
- Male
- Mice
- Plant Extracts
(administration & dosage, chemistry, pharmacology)
- Plants, Medicinal
(chemistry)
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