[Nonmyeloablative stem cell transplantation with low-dose total body irradiation (200 cGy) for a 55-year-old woman with acute lymphoblastic leukemia].

Abstract

We describe a 55-year-old woman with acute lymphoblastic leukemia (ALL) in the first remission who underwent nonmyeloablative stem cell transplantation with conditioning consisting of low-dose total body irradiation and postgrafting cyclosporine and mycophenolate mofetil. Myelosuppression was mild, but on day 28 her bone marrow showed 8.8% lymphoblasts. We withdrew the cyclosporine, but the patient developed grade 2 acute GVHD and eosinophilia. The proportion of bone marrow lymphoblasts decreased transiently to 1.0% on day 40, but later increased again and the patient died on day 85. Application of this approach to patients with ALL needs to be examined on a large scale.

• Authors: Y Abe, K Hara, I Choi, M Shiratsuchi, T Matsushima, R Minami, T Kihara, J Nishimura, S Inaba, H Nawata, K Muta
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 41 Issue 12 Pg. 1277-80 (Dec 2000) ISSN: 0485-1439 [Print] Japan
• PMID: 11201154 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunosuppressive Agents
• Cyclosporine
• Mycophenolic Acid

Topics

• Cyclosporine (administration & dosage)
• Female
• Hematopoietic Stem Cell Transplantation
• Humans
• Immunosuppressive Agents (administration & dosage)
• Middle Aged
• Mycophenolic Acid (administration & dosage, analogs & derivatives)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (therapy)
• Transplantation Conditioning
• Whole-Body Irradiation