An infant with homozygous hemoglobin D-Iran.

Abstract

Hemoglobin D-Iran (Hb D-Iran, beta 22 Glu-->Gln) is a beta-chain variant that was first described in 1973. Hb D-Iran in combination with normal Hb A (Hb D-Iran trait) is a benign condition. Hb D-Iran has also been described in combination with sickle hemoglobin and beta thalassemia, but never as a homozygous mutation. The authors describe a case of homozygous Hb D-Iran in an infant of Pakistani descent. The hematologic values, hemoglobin electrophoresis, peripheral blood smear, and clinical course to date suggest that homozygous Hb D-Iran is a relatively benign condition with mild microcytic anemia, poikilocytosis, and minimal hemolysis.

• Authors: C D Thornburg, S A Zimmerman, W H Schultz, R E Ware
• Journal: Journal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 23 Issue 1 Pg. 67-8 (Jan 2001) ISSN: 1077-4114 [Print] United States
• PMID: 11196276 (Publication Type: Case Reports, Journal Article)

Chemical References

• Hemoglobins, Abnormal
• hemoglobin D Iran
• Fetal Hemoglobin

Topics

• Anemia (blood, genetics)
• Erythrocytes, Abnormal
• Fetal Hemoglobin (analysis)
• Hemoglobins, Abnormal (analysis, genetics)
• Hemolysis
• Homozygote
• Humans
• Infant
• Male
• North Carolina
• Pakistan (ethnology)