Abstract |
Although diverse peptides are known to affect invertebrate cardiac activity, the peptidergic regulation of the cardiovascular system of Aplysia is still poorly understood. Asn-D-Trp-Phe-NH(2) ( NdWFamide) is a recently purified cardioactive peptide in Aplysia. Pharmacological experiments showed that NdWFamide was one of the most potent cardioexcitatory peptides among the known endogenous cardioactive peptides in Aplysia. NdWFamide-immunopositive neuronal processes were abundant in the cardiovascular region of Aplysia, and many of them originated from neurosecretory cells in the abdominal ganglion (R3-R13 cells). The data suggest that NdWFamide is a cardioexcitatory peptide utilized by R3-R13 cells of Aplysia.
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Authors | F Morishita, K Sasaki, K Kanemaru, Y Nakanishi, O Matsushima, Y Furukawa |
Journal | Peptides
(Peptides)
Vol. 22
Issue 2
Pg. 183-9
(Feb 2001)
ISSN: 0196-9781 [Print] United States |
PMID | 11179811
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Oligopeptides
- asparaginyl-tryptophyl-phenylalaninamide
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Topics |
- Animals
- Aplysia
(physiology)
- Cardiovascular System
(innervation, metabolism)
- Ganglia
(physiology)
- Immunohistochemistry
- Oligopeptides
(metabolism)
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