Abstract | AIM: T- prolymphocytic leukemia (T-PLL) is a rare disease of the elderly characterized by a high white blood cell count and organomegaly, and is currently incurable. Our aim was to elicit graft-versus- leukemia reactions in a patient with T-PLL. METHODS: RESULTS: There was no treatment related toxicity other than neutropenia. Engraftment was successful. The patient experienced no graft-versus-host disease (GVHD) at any time but, on day 84 after transplantation, had a relapse in the central nervous system. Despite infusion of donor lymphocytes and intralumbar chemotherapy, she died on day 157 of systemic disease. CONCLUSION: The reasons why treatment may have failed are discussed (nature of disease, disease progression, treatment schedule).
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Authors | L Garderet, H Bittencourt, A Kaliski, M Daniel, P Ribaud, G Socié, E Gluckman |
Journal | European journal of haematology
(Eur J Haematol)
Vol. 66
Issue 2
Pg. 137-9
(Feb 2001)
ISSN: 0902-4441 [Print] England |
PMID | 11168523
(Publication Type: Case Reports, Journal Article)
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Topics |
- Facial Nerve Diseases
(etiology)
- Fatal Outcome
- Female
- Graft Survival
- Graft vs Leukemia Effect
- Hematopoietic Stem Cell Transplantation
- Histocompatibility Testing
- Humans
- Leukemia, Prolymphocytic
(therapy)
- Leukemia, T-Cell
(therapy)
- Meningitis
(etiology)
- Middle Aged
- Nuclear Family
- Recurrence
- Transplantation, Homologous
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