Mechanisms mediating Porphyromonas gingivalis gingipain RgpA-induced oral mucosa inflammation in vivo.

Abstract

Suffusion of gingipain RgpA (GRgpA) elicited a significant concentration-dependent increase in the clearance of macromolecules from in situ hamster cheek pouch which was attenuated by NPC 17647, a selective bradykinin B(2) receptor antagonist. Leupeptin and a mixture of proteinase inhibitors also attenuated GRgpA-induced responses. These data indicate that GRgpA elicits plasma exudation from in situ oral mucosa in a catalytic site-dependent fashion by elaborating bradykinin.

• Authors: I Rubinstein, J Potempa, J Travis, X P Gao
• Journal: Infection and immunity (Infect Immun) Vol. 69 Issue 2 Pg. 1199-201 (Feb 2001) ISSN: 0019-9567 [Print] United States
• PMID: 11160022 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Adhesins, Bacterial
• Gingipain Cysteine Endopeptidases
• Hemagglutinins
• Leupeptins
• Receptor, Bradykinin B2
• Receptors, Bradykinin
• Cysteine Endopeptidases
• leupeptin
• Bradykinin
• Indomethacin

Topics

• Adhesins, Bacterial (toxicity)
• Animals
• Bradykinin (physiology)
• Capillary Permeability (drug effects)
• Catalytic Domain
• Cricetinae
• Cysteine Endopeptidases (toxicity)
• Gingipain Cysteine Endopeptidases
• Hemagglutinins (toxicity)
• Indomethacin (pharmacology)
• Leupeptins (pharmacology)
• Male
• Mesocricetus
• Mouth Mucosa (drug effects)
• Periodontitis (drug therapy, etiology)
• Receptor, Bradykinin B2
• Receptors, Bradykinin (physiology)