RIZ, the retinoblastoma protein interacting zinc finger gene, is mutated in genetically unstable cancers of the pancreas, stomach, and colorectum.

Abstract

The retinoblastoma protein interacting zinc finger (RIZ) gene is a candidate tumor suppressor gene on 1p36, a region frequently rearranged in a wide variety of human tumors. As the RIZ gene harbors several microsatellites within its coding region, it is a candidate for an inactivating mutation in microsatellite instability (MSI) mediated carcinogenesis. In this study, we examined mutations of two poly adenine tracts, A(8) and A(9), within the coding region of the RIZ gene, in MSI-high (MSI-H) primary cancers occurring in the pancreas, stomach, and colorectum. Frameshift mutations were found in one (10%) of 10 pancreatic, four (36%) of 11 gastric, and two (25%) of eight colorectal cancers. These results indicate that mutations of the RIZ gene play an important role in the pathogenesis of some MSI-H cancers.

• Authors: K Sakurada, T Furukawa, Y Kato, T Kayama, S Huang, A Horii
• Journal: Genes, chromosomes & cancer (Genes Chromosomes Cancer) Vol. 30 Issue 2 Pg. 207-11 (Feb 2001) ISSN: 1045-2257 [Print] United States
• PMID: 11135439 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2000 Wiley-Liss, Inc.

Chemical References

• DNA-Binding Proteins
• Nuclear Proteins
• Retinoblastoma Protein
• Transcription Factors
• Histone-Lysine N-Methyltransferase
• PRDM2 protein, human

Topics

• Colorectal Neoplasms (genetics)
• DNA-Binding Proteins
• Frameshift Mutation (genetics)
• Genes, Tumor Suppressor (genetics)
• Histone-Lysine N-Methyltransferase
• Humans
• Microsatellite Repeats (genetics)
• Mutation
• Nuclear Proteins (genetics)
• Pancreatic Neoplasms (genetics)
• Retinoblastoma Protein (genetics)
• Sequence Deletion (genetics)
• Stomach Neoplasms (genetics)
• Transcription Factors
• Zinc Fingers (genetics)