[Effectiveness of docetaxel plus cisplatin in large cell lung cancer showing little response to prior chemotherapy with MVP].

Abstract

The present patient was a 53-year-old male who had large cell lung cancer of c-T4N1M0. We administered multi-drug regimen including mitomycin C, vindesine and cisplatin (CDDP) because of cancer invasion into the great vessels seen on a chest CT. After 3 courses, the cancer showed no change in size. Therefore, we adopted chemotherapy of docetaxel (Taxotere: TXT) and CDDP. After 4 courses, the size of the mass had decreased (partial response). The only major toxic defect was grade 3 neutropenia. A good response to TXT and CDDP could lead to complete resection of lung cancer. It is suggested that TXT is effective in the treatment of large cell lung cancer.

• Authors: T Saito, T Ishida, H Aoki, K Kuwahara, Y Minegishi, K Watanabe, T Okano, K Hashimoto, K Hayashihara, S Watanabe, E Nemoto, S Fukai, N Yanai
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 27 Issue 13 Pg. 2109-12 (Nov 2000) ISSN: 0385-0684 [Print] Japan
• PMID: 11103243 (Publication Type: Case Reports, Journal Article)

Chemical References

• Taxoids
• Docetaxel
• Mitomycin
• Paclitaxel
• Cisplatin
• Vindesine

Topics

• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Carcinoma, Large Cell (drug therapy)
• Cisplatin (administration & dosage)
• Docetaxel
• Drug Administration Schedule
• Humans
• Lung Neoplasms (drug therapy)
• Male
• Middle Aged
• Mitomycin (administration & dosage)
• Paclitaxel (administration & dosage, analogs & derivatives)
• Taxoids
• Treatment Failure
• Vindesine (administration & dosage)