Abstract | OBJECTIVES: BACKGROUND: METHODS: RESULTS: The PCr/ ATP was significantly reduced in patients (1.55+/-0.37) and carriers (1.37+/-0.25) as compared with control subjects (2.44+/-0.33; p<0.0001 for both groups). The PCr/ ATP did not correlate with LV ejection fraction or mass index. CONCLUSIONS: Altered expression of dystrophin leads to a reduction in the PCr/ ATP. Since this reduction did not correlate with indexes of left ventricular function, this raises the possibility of a direct link between altered dystrophin expression and the development of cardiomyopathy in such patients.
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Authors | J G Crilley, E A Boehm, B Rajagopalan, A M Blamire, P Styles, F Muntoni, D Hilton-Jones, K Clarke |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 36
Issue 6
Pg. 1953-8
(Nov 15 2000)
ISSN: 0735-1097 [Print] United States |
PMID | 11092670
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Phosphocreatine
- Adenosine Triphosphate
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Topics |
- Adenosine Triphosphate
(analysis)
- Adult
- Cardiomyopathies
(etiology, metabolism, physiopathology)
- Energy Metabolism
- Female
- Humans
- Magnetic Resonance Spectroscopy
- Male
- Middle Aged
- Muscular Dystrophy, Duchenne
(complications, metabolism, physiopathology)
- Myocardium
(metabolism)
- Phosphocreatine
(analysis)
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