[Serum cobalt and serum chromium level in 2 patients with chronic renal failure after total hip prosthesis implantation with metal-metal gliding contact].

Abstract

PURPOSE:

The influence of chronic renal failure on serum cobalt and serum chromium in two patients with metal-on-metal bearing (Metasul) and cementless total hip arthroplasty (Alloclassic) is investigated.

METHODS:

Serum cobalt and serum chronium levels were determined in the postoperative course using atomic absorption spectrometry.

RESULTS:

Maximum values are found to be more than 100-fold elevated when compared to the reported median serum cobalt concentrations in patients with the same prosthesis type and no known renal disease.

CONCLUSION:

Chronic renal failure seems to be responsible for the marked elevation of serum cobalt and serum chromium.

CLINICAL RELEVANCE:

Despite evidence of adverse health reactions, a possible effect of long-term cobalt and chromium loading cannot be neglected. In our opinion, metal-on-metal bearings in THA should not be inserted in patients with chronic renal failure. Follow-up investigations (serum cobalt, serum chromium, serum creatinine, BUN, echocardiography) should be performed at short intervals.

• Authors: W Brodner, J G Grohs, P Bitzan, V Meisinger, J Kovarik, R Kotz
• Journal: Zeitschrift fur Orthopadie und ihre Grenzgebiete (Z Orthop Ihre Grenzgeb) 2000 Sep-Oct Vol. 138 Issue 5 Pg. 425-9 ISSN: 0044-3220 [Print] Germany
• Vernacular Title: Serumcobalt- und Serumchromspiegel bei zwei chronisch niereninsuffizienten Patientinnen mit Hüfttotalendoprothese und Metall-Metall-Gleitpaarung.
• PMID: 11084743 (Publication Type: Comparative Study, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Chromium
• Cobalt

Topics

• Adult
• Arthroplasty, Replacement, Hip
• Chromium (blood)
• Cobalt (blood)
• Female
• Follow-Up Studies
• Humans
• Kidney Failure, Chronic (blood)
• Kidney Function Tests
• Postoperative Complications (blood)
• Prosthesis Design