Ability of 3 different meningococcal C conjugate vaccines to induce immunologic memory after a single dose in UK toddlers.

Abstract

To test for immunologic memory after a single dose of meningococcal C conjugate (MCC) vaccine in toddlers, 226 children 12-18 months old were randomized to receive 1 of 3 MCC vaccines, with a C polysaccharide booster 6 months later. The protein conjugate was diphtheria mutant toxoid in 2 vaccines (MCC-CRM(197)) and was tetanus toxoid in the third (MCC-TT). One month after the MCC vaccines, 91%-100% of children had serum bactericidal antibody (SBA) titers > or =8, and 89%-100% had a > or =4-fold increase. Geometric mean titer (GMT) increased from <4 to 215 (95% confidence interval [CI], 166-279). MCC-TT induced higher SBA GMTs (P<.001) and higher proportions with SBA > or =8 (P=.02) than did the MCC-CRM(197) vaccines. By 6 months, GMTs had decreased to 55.1 (95% CI, 40-76), but IgG antibody avidity increased (P<.001). Induction of immunologic memory was confirmed by a GMT of 1977 (range, 1535-2547) after the polysaccharide booster and a further increase in avidity. This evidence justified the use of a single dose in a catch-up immunization program for children 1-18 years old.

• Authors: P Richmond, R Borrow, D Goldblatt, J Findlow, S Martin, R Morris, K Cartwright, E Miller
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 183 Issue 1 Pg. 160-3 (Jan 01 2001) ISSN: 0022-1899 [Print] United States
• PMID: 11078484 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Bacterial
• Diphtheria Toxoid
• Immunoglobulin G
• Meningococcal Vaccines
• Polysaccharides, Bacterial
• Tetanus Toxoid
• Vaccines, Combined
• Vaccines, Conjugate

Topics

• Antibodies, Bacterial (blood)
• Antibody Affinity
• Diphtheria Toxoid (immunology)
• Female
• Humans
• Immunoglobulin G (blood)
• Immunologic Memory
• Infant
• Male
• Meningitis, Bacterial (blood, prevention & control)
• Meningococcal Vaccines (administration & dosage, immunology)
• Polysaccharides, Bacterial (immunology)
• Tetanus Toxoid (immunology)
• United Kingdom
• Vaccination
• Vaccines, Combined (administration & dosage, immunology)
• Vaccines, Conjugate (administration & dosage, immunology)