Abstract |
Following hypoglossal nerve transection, the microglia of the rat hypoglossal nucleus expressed protein kinase CK2 beta subunit immunoreactivity. CK2 beta immunostaining occurred on the operated side from postoperative day 3; on day 5 we observed strong immunoreactivity and the immunopositive microglial cell processes surrounded the injured neurones. Thereafter, the immunoreactivity decreased gradually and on day 10 the immunopositive cells surrounded only a few injured neurones. Electron microscopic observations on the hypoglossal nucleus revealed microglia-neuronal contact within 3 hours of nerve injury, and by day 3 all the injured neurones were in contact with microglial cells. These observations indicated that microglia-neuronal contact occurred earlier than the CK2 beta subunit immunoreactivity. CK2 may not be implicated during the initial migration of the microglia to the injured neurones; however, it may enhance the growth and elongation of the microglial cell processes around the injured neurones.
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Authors | A P Gesase, H Kiyama |
Journal | Journal of neurocytology
(J Neurocytol)
Vol. 29
Issue 1
Pg. 61-6
(Jan 2000)
ISSN: 0300-4864 [Print] United States |
PMID | 11068334
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Casein Kinase II
- Protein Serine-Threonine Kinases
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Topics |
- Animals
- Axotomy
- Casein Kinase II
- Hypoglossal Nerve
(chemistry, cytology, surgery)
- Male
- Microglia
(chemistry, enzymology, ultrastructure)
- Microscopy, Electron
- Neurons
(ultrastructure)
- Protein Serine-Threonine Kinases
(analysis, biosynthesis)
- Rats
- Rats, Sprague-Dawley
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