Decreased protein C activation is associated with abnormal collagen turnover in the intraalveolar space of patients with interstitial lung disease.

Abstract

Activation of the coagulation system in the alveolar space plays an important role in the pathogenesis of interstitial lung disease (ILD) and pulmonary fibrosis. The protein C (PC) pathway is the main modulator of coagulation activation. This study evaluated whether dysfunction of the PC pathway is associated with increased collagen synthesis in the intraalveolar space of patients with ILD. This study comprised 22 patients with ILD; of these, five had idiopathic pulmonary fibrosis (IPF), nine had sarcoidosis-associated ILD, and eight had collagen vascular disease-associated ILD (CVD-ILD). Thrombin-antithrombin complex (TAT) was measured as a marker of coagulation activation. As markers of the PC pathway activity, the concentration of activated PC-PC inhibitor (APC-PCI) complex and the APC-PCI/PC ratio were measured and, as a marker of collagen synthesis, the concentration of aminoterminal propeptide of type III procollagen (PIIINP) was measured in bronchoalveolar lavage fluid (BALF) of ILD patients. TAT was significantly increased in BALF from ILD patients as compared to control subjects. The concentrations of PIIINP were significantly elevated in patients with ILD as compared to healthy subjects. In contrast, the concentration of APC-PCI and the values of APC-PCI/PC ratio were significantly decreased in BALF from patients with ILD. BALF concentration of PIIINP was significantly and inversely correlated with the concentration of APC-PCI and with the APC-PCI/PC ratio. These findings suggest that dysfunction of the protein C pathway may have important physiopathologic implications in the development of pulmonary fibrosis in ILD.

• Authors: H Yasui, E C Gabazza, O Taguchi, J Risteli, L Risteli, H Wada, H Yuda, T Kobayashi, H Kobayashi, K Suzuki, Y Adachi
• Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis (Clin Appl Thromb Hemost) Vol. 6 Issue 4 Pg. 202-5 (Oct 2000) ISSN: 1076-0296 [Print] United States
• PMID: 11030525 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Hemostatics
• Procollagen
• Protein C
• Collagen

Topics

• Biomarkers
• Blood Coagulation
• Bronchoalveolar Lavage
• Collagen (metabolism)
• Enzyme Activation
• Female
• Hemostatics
• Humans
• Lung Diseases, Interstitial (etiology, metabolism)
• Male
• Procollagen (blood)
• Protein C (metabolism)
• Pulmonary Alveoli (metabolism)
• Statistics, Nonparametric