Histologic transformation of follicular lymphoma after allogeneic bone marrow transplantation.

Abstract

A 38-year-old man with refractory follicular lymphoma underwent allogeneic BMT from an HLA-identical sibling donor. He had generalized lymphadenopathy, hepatosplenomegaly and lymphoma infiltration of the marrow, all of which disappeared within 3 months following transplantation. Six months post-transplant, progressive hepatomegaly developed in the absence of splenomegaly and lymphadenopathy, and he died from hepatic failure. Autopsy disclosed diffuse large B cell lymphoma of the liver, into which the follicular lymphoma had transformed. Future issues to be investigated should include the optimal timing of allogeneic BMT for low-grade lymphomas.

• Authors: K Kojima, T Mannami, T Yoshino, H Kawasaki, K Sasaki, T Maeda, K Furuya, M Harada, M Hara
• Journal: Bone marrow transplantation (Bone Marrow Transplant) Vol. 26 Issue 5 Pg. 581-3 (Sep 2000) ISSN: 0268-3369 [Print] England
• PMID: 11019852 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Bone Marrow Transplantation (adverse effects)
• Cell Transformation, Neoplastic (pathology)
• Fatal Outcome
• Hepatomegaly (etiology)
• Humans
• Liver (pathology)
• Lymphoma, B-Cell (genetics, pathology)
• Lymphoma, Follicular (genetics, pathology, therapy)
• Lymphoma, Large B-Cell, Diffuse (genetics, pathology)
• Male
• Neoplasms, Second Primary (genetics, pathology)
• Sequence Analysis, DNA
• Sequence Homology
• Transplantation, Homologous (adverse effects)