Low apolipoprotein A-IV plasma concentrations in men with coronary artery disease.

Abstract

OBJECTIVES:

The objective of this study was to evaluate the relation between apolipoprotein A-IV (apoA-IV) plasma concentrations and coronary artery disease (CAD).

BACKGROUND:

Experimental in vitro and in vivo studies favor apoA-IV to be protective against the development of atherosclerosis. Mice that overexpress either human or mouse apoA-IV demonstrated a significant reduction of aortic atherosclerotic lesions compared with control mice. Data on apoA-IV plasma concentrations and CAD in humans are lacking.

METHODS:

We determined in two independent case-control studies of a Caucasian and an Asian Indian population whether apoA-IV plasma concentrations are related to the presence of angiographically assessed CAD.

RESULTS:

Plasma apoA-IV levels were significantly lower in 114 male Caucasian subjects with angiographically defined CAD when compared with 114 age-adjusted male controls (10.2 +/-3.8 mg/dL vs. 15.1 +/- 4.0 mg/dL, p < 0.001). Logistic regression analysis indicated that the association between apoA-IV levels and CAD was independent of the high-density lipoprotein cholesterol and triglyceride concentrations. The inverse relationship between plasma levels of apoA-IV and the presence of CAD was confirmed in an independent sample of 68 male Asian Indians with angiographically documented CAD and 68 age-matched controls.

CONCLUSIONS:

The results of this cross-sectional study demonstrate for the first time an association between low apoA-IV concentrations and CAD in humans and suggest that apoA-IV may play an antiatherogenic role in humans.

• Authors: F Kronenberg, M Stühlinger, E Trenkwalder, F S Geethanjali, O Pachinger, A von Eckardstein, H Dieplinger
• Journal: Journal of the American College of Cardiology (J Am Coll Cardiol) Vol. 36 Issue 3 Pg. 751-7 (Sep 2000) ISSN: 0735-1097 [Print] United States
• PMID: 10987595 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Apolipoproteins A
• Cholesterol, HDL
• Triglycerides
• apolipoprotein A-IV

Topics

• Apolipoproteins A (blood)
• Austria
• Case-Control Studies
• Cholesterol, HDL (blood)
• Coronary Disease (blood, ethnology)
• Cross-Sectional Studies
• Ethnicity
• Humans
• India
• Male
• Middle Aged
• Osmolar Concentration
• Reference Values
• Regression Analysis
• Triglycerides (blood)
• White People