Improvement in cardiac function and free fatty acid metabolism in a case of dilated cardiomyopathy with CD36 deficiency.

Abstract

A 27-year-old man diagnosed as having dilated cardiomyopathy (DCM) without myocardial accumulation of 123I-beta-methyl-iodophenylpentadecanoic acid, and he was found to have type I CD36 deficiency. This abnormality of cardiac free fatty acid metabolism was also confirmed by other methods: 18F-fluoro-2-deoxyglucose positron emission tomography, measurements of myocardial respiratory quotient and cardiac fatty acid uptake. Although the type I CD36 deficiency was reconfirmed after 3 months, the abnormal free fatty acid metabolism improved after carvedilol therapy and was accompanied by improved cardiac function. Apart from a cause-and-effect relationship, carvedilol can improve cardiac function and increase free fatty acid metabolism in patients with both DCM and CD36 deficiency.

• Authors: K Hirooka, Y Yasumura, Y Ishida, K Komamura, A Hanatani, S Nakatani, M Yamagishi, K Miyatake
• Journal: Japanese circulation journal (Jpn Circ J) Vol. 64 Issue 9 Pg. 731-5 (Sep 2000) ISSN: 0047-1828 [Print] Japan
• PMID: 10981864 (Publication Type: Case Reports, Journal Article)

Chemical References

• Adrenergic beta-Antagonists
• CD36 Antigens
• Carbazoles
• Fatty Acids
• Fatty Acids, Nonesterified
• Iodobenzenes
• Propanolamines
• Radiopharmaceuticals
• iodofiltic acid
• Carvedilol
• Fluorodeoxyglucose F18

Topics

• Adrenergic beta-Antagonists (administration & dosage)
• Adult
• CD36 Antigens (metabolism)
• Carbazoles (administration & dosage)
• Cardiomyopathy, Dilated (diagnostic imaging, metabolism, physiopathology)
• Carvedilol
• Fatty Acids (pharmacokinetics)
• Fatty Acids, Nonesterified (metabolism)
• Fluorodeoxyglucose F18 (pharmacokinetics)
• Heart Function Tests (methods)
• Humans
• Iodobenzenes (pharmacokinetics)
• Male
• Propanolamines (administration & dosage)
• Radionuclide Imaging
• Radiopharmaceuticals (pharmacokinetics)