Chemoradiation therapy for squamous cell carcinoma of anal canal cancer: report of a case.

Abstract

We report a case of anal canal cancer in a 65-year-old woman who had complained of bloody stool. Physical examination revealed a 2.5 cm ulcerated tumor in the anterior wall of the anal canal astride the dentate line. Histological examination of biopsy specimens confirmed the diagnosis of moderately differentiated squamous cell carcinoma. Chemoradiation therapy included whole pelvic irradiation amounting to 4140 cGy followed by conformal boost irradiation of 2000 cGy and 5-fluorouracil div 750 mg/24 hr 3 days, mitomycin C iv 10 mg day 1, and cisplatinum div 50 mg day 2. Six weeks later the tumor had completely regressed, and there was no evidence of recurrence 21 months later. Her anorectal function was retained.

• Authors: H Ando, T Nishimura, T Nakamura, H Sugimura, S Nakamura
• Journal: Radiation medicine (Radiat Med) 2000 May-Jun Vol. 18 Issue 3 Pg. 199-203 ISSN: 0288-2043 [Print] Japan
• PMID: 10972551 (Publication Type: Case Reports, Journal Article)

Chemical References

• Mitomycin
• Cisplatin
• Fluorouracil

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Anus Neoplasms (drug therapy, radiotherapy)
• Carcinoma, Squamous Cell (drug therapy, radiotherapy)
• Cisplatin (administration & dosage)
• Combined Modality Therapy
• Female
• Fluorouracil (administration & dosage)
• Humans
• Mitomycin (administration & dosage)
• Radiotherapy Dosage