Inhibitory effect of mast cell-mediated immediate-type allergic reactions by sulfapyridine.

Abstract

We examined the effect of sulfapyridine on mast cell-mediated immediate-type allergic reactions. Sulfapyridine (1 and 10 microg/kg) significantly inhibited systemic allergic reaction induced by compound 48/80 in rats. Sulfapyridine (1 and 10 microg/kg) also inhibited significantly local mast cell-mediated immediate-type allergic reactions activated by anti-dinitrophenyl (DNP) IgE. Moreover, sulfapyridine inhibited histamine release dose-dependently in the rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. When sulfapyridine was added, the level of cAMP in RPMC, transiently and significantly increased about 4-fold compared with that of basal cells. These results indicate that sulfapyridine inhibits mast cell-mediated immediate-type allergic reactions in vivo and in vitro.

• Authors: H M Kim, N H An, B H Yi, H J Chae, H R Kim, S J Moon, J J Kim, S T Park, S H Baek
• Journal: Immunopharmacology and immunotoxicology (Immunopharmacol Immunotoxicol) Vol. 22 Issue 2 Pg. 253-66 (May 2000) ISSN: 0892-3973 [Print] England
• PMID: 10952030 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Dinitrophenols
• Serum Albumin
• dinitrophenyl-human serum albumin conjugate
• p-Methoxy-N-methylphenethylamine
• Cyclic AMP
• Sulfapyridine

Topics

• Animals
• Cyclic AMP (metabolism)
• Dinitrophenols (immunology)
• Histamine Release (drug effects)
• Hypersensitivity, Immediate (prevention & control)
• Immunity, Cellular (drug effects)
• In Vitro Techniques
• Mast Cells (drug effects, immunology, metabolism)
• Passive Cutaneous Anaphylaxis (drug effects)
• Peritoneal Cavity (cytology)
• Rats
• Rats, Wistar
• Serum Albumin (immunology)
• Sulfapyridine (pharmacology)
• p-Methoxy-N-methylphenethylamine (pharmacology)