Abstract |
Cefodizime is a third generation cephalosporin for parenteral use. The pharmacokinetics of this cephem antibiotic were determined in serum and skin suction blister fluid (SBF) after intravenous (i.v.) or intramuscular (i.m.) administration of a single 1 g dose in 8 adult patients with normal renal and hepatic function who volunteered for the study. The concentration versus time curve showed a slower elimination rate from the extravascular compartment: the half-lives were 4.4+/-0.5 and 5.4+/-0.4 hours after i.v. and i.m. route respectively. The relatively long elimination half-life in SBF with a mean residence time of about 8 hours allows the use of cefodizime once-a-day for the treatment of infections due to sensitive pathogens.
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Authors | T Mazzei, A Novelli, S Esposito, S Fallani, S Noviello, M I Cassetta, S Conti, P Periti |
Journal | Journal of chemotherapy (Florence, Italy)
(J Chemother)
Vol. 12
Issue 4
Pg. 306-13
(Aug 2000)
ISSN: 1120-009X [Print] England |
PMID | 10949980
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Cephalosporins
- Cefotaxime
- cefodizime
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Topics |
- Adult
- Blister
(metabolism)
- Body Fluids
(metabolism)
- Cefotaxime
(analogs & derivatives, blood, pharmacokinetics)
- Cephalosporins
(blood, pharmacokinetics)
- Humans
- Infusions, Intravenous
- Injections, Intramuscular
- Kidney Function Tests
- Liver Function Tests
- Male
- Respiratory Tract Diseases
(blood, metabolism)
- Skin
(metabolism)
- Suction
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