Cl(-) secretion in colonic epithelial cells induced by the vibrio parahaemolyticus hemolytic toxin related to thermostable direct hemolysin.

Abstract	A hemolytic toxin related to thermostable direct hemolysin (TDH), TDH-related hemolysin (TRH), produced by Kanagawa-phenomenon-negative Vibrio parahaemolyticus is suspected of playing an important, but yet-to-be-elucidated role in diarrhea caused by this organism. In cultured human colonic epithelial cells, TRH increases Cl(-) secretion, followed by elevation of intracellular calcium.
Authors	A Takahashi, N Kenjyo, K Imura, Y Myonsun, T Honda
Journal	Infection and immunity (Infect Immun) Vol. 68 Issue 9 Pg. 5435-8 (Sep 2000) ISSN: 0019-9567 [Print] United States
PMID	10948178 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	CFTR protein, human Chlorides Hemolysin Proteins Cystic Fibrosis Transmembrane Conductance Regulator 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid Calcium
Topics	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid (pharmacology) Caco-2 Cells Calcium (metabolism) Chlorides (metabolism) Cystic Fibrosis Transmembrane Conductance Regulator (drug effects) Hemolysin Proteins (toxicity) Humans Vibrio parahaemolyticus (pathogenicity)

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