Hepatocyte growth factor in renal regeneration, renal disease and potential therapeutics.

Abstract

Hepatocyte growth factor (HGF) has mitogenic, motogenic, morphogenic, and anti-apoptotic activities on renal cells and is a potential renotropin for renal protection and repair. In chronic renal failure/fibrosis, HGF in the kidney declines in a reciprocal manner to the increase in transforming growth factor-beta (TGF-beta). Neutralization of HGF by the antibody leads to acceleration of renal failure/fibrosis while HGF administration leads to remarkable attenuation, thus indicating the importance of HGF versus TGF-beta counterbalance in both pathogenesis and therapeutics in cases of chronic renal failure. HGF is being strongly considered for potential treatment of acute and chronic renal failure.

• Authors: K Matsumoto, S Mizuno, T Nakamura
• Journal: Current opinion in nephrology and hypertension (Curr Opin Nephrol Hypertens) Vol. 9 Issue 4 Pg. 395-402 (Jul 2000) ISSN: 1062-4821 [Print] England
• PMID: 10926176 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Transforming Growth Factor beta
• Hepatocyte Growth Factor

Topics

• Animals
• Hepatocyte Growth Factor (physiology)
• Humans
• Kidney (physiology, physiopathology)
• Kidney Diseases (physiopathology, therapy)
• Kidney Failure, Chronic (physiopathology, therapy)
• Regeneration (physiology)
• Transforming Growth Factor beta (physiology)