Abstract | OBJECTIVE: METHODS: RESULTS: In 49 photosentizers, the structure formula of the leading 9 single photosensitizers belonged to homatoporphyrin group, the average IC50 of which was < or = 1.0 microgram/ml on both cell lines of. The photosensitizers currently used in the clinic, hematoporphyrin-3 (PSD-007), ranked 17th, with IC50 on both cell lines of 1.25 micrograms/ml and 3.75 micrograms/ml, respecively. CONCLUSION: The leading 16 single photosensitizer in ths series studied are better purified and more effective in photodynamic killing of human cancer cell lines in vitro. They can be used in lieu of PSD-007 for cancer treatment.
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Authors | L He, S Zhang, L Yu |
Journal | Zhonghua zhong liu za zhi [Chinese journal of oncology]
(Zhonghua Zhong Liu Za Zhi)
Vol. 19
Issue 6
Pg. 431-3
(Nov 1997)
ISSN: 0253-3766 [Print] China |
PMID | 10920875
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Hematoporphyrins
- Photosensitizing Agents
- Radiation-Sensitizing Agents
- photocarcinorin
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Topics |
- Colorectal Neoplasms
(drug therapy, pathology)
- Hematoporphyrin Photoradiation
- Hematoporphyrins
(pharmacology)
- Humans
- K562 Cells
(drug effects)
- Photosensitizing Agents
(pharmacology)
- Radiation-Sensitizing Agents
(pharmacology)
- Tumor Cells, Cultured
(drug effects)
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