Abstract |
The DRD4 exon III repeat polymorphism has been associated in adults with Novelty Seeking personality traits and in children with attention deficit hyperactivity disorder ( ADHD) in some but not all studies. In a previous report we failed to observe preferential transmission of the long DRD4 repeat in ADHD compared to the haplotype relative risk (HRR) derived control group in a group of 49 triads (both parents and ADHD child) recruited in the Jerusalem area. In the current study we independently recruited an additional group of 49 triads from a different geographical location (Petak Tikvah) in Israel but having a similar ethnic background. In contrast to previous findings from a number of groups, in the current study an excess of the long DRD4 alleles was observed in the HRR control group compared to the ADHD subjects (Likelihood ratio = 5.50, P = 0. 02). In the expanded Israeli group of 98 triads so-far examined for the DRD4 repeat polymorphism there is an excess of the long alleles in the HRR control group (Likelihood ratio = 3.81, P = 0.05). These results attest to the complexity of ADHD inheritance and the likelihood that genetic heterogeneity characterizes this disorder especially across ethnic and cultural boundaries.
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Authors | M Kotler, I Manor, Y Sever, J Eisenberg, H Cohen, R P Ebstein, S Tyano |
Journal | American journal of medical genetics
(Am J Med Genet)
Vol. 96
Issue 3
Pg. 278-81
(Jun 12 2000)
ISSN: 0148-7299 [Print] United States |
PMID | 10898899
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- DRD4 protein, human
- Receptors, Dopamine D2
- Receptors, Dopamine D4
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Topics |
- Adolescent
- Alleles
- Attention Deficit Disorder with Hyperactivity
(genetics)
- Child
- Exons
- Female
- Gene Frequency
- Haplotypes
- Humans
- Likelihood Functions
- Male
- Polymorphism, Genetic
- Receptors, Dopamine D2
(genetics)
- Receptors, Dopamine D4
- Reproducibility of Results
- Risk Factors
- Tandem Repeat Sequences
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