Abstract | BACKGROUND: METHODS: Patients with a systolic pulmonary arterial pressure of 50% or more of the systolic systemic arterial pressure during the early postoperative period were randomized to receive 20 parts per million inhaled nitric oxide (n = 20) or conventional therapy alone (n = 20). Acute hemodynamic and blood gas measurements were performed at the onset of therapy. The efficacy of sustained therapy was determined by comparing the number of patients in each group who experienced a pulmonary hypertensive crisis. RESULTS: In comparison to controls, there were no significant differences in the baseline and 1-hour measurements of patients who were treated with nitric oxide. Four patients in the control group and 3 patients in the nitric oxide group experienced a pulmonary hypertensive crisis. CONCLUSIONS:
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Authors | R W Day, J A Hawkins, E C McGough, K L Crezeé, G S Orsmond |
Journal | The Annals of thoracic surgery
(Ann Thorac Surg)
Vol. 69
Issue 6
Pg. 1907-12; discussion 1913
(Jun 2000)
ISSN: 0003-4975 [Print] Netherlands |
PMID | 10892945
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Vasodilator Agents
- Nitric Oxide
|
Topics |
- Administration, Inhalation
- Child, Preschool
- Female
- Heart Defects, Congenital
(surgery)
- Hemodynamics
(drug effects)
- Humans
- Hypertension, Pulmonary
(drug therapy)
- Infant
- Infant, Newborn
- Male
- Nitric Oxide
(administration & dosage)
- Postoperative Complications
(drug therapy)
- Pulmonary Circulation
(drug effects)
- Pulmonary Gas Exchange
(drug effects)
- Treatment Outcome
- Vascular Resistance
(drug effects)
- Vasodilator Agents
(administration & dosage)
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