[Synergic effects of intra-aortic counterpulsation and dopamine in experimental cardiogenic shock with closed thorax].

Abstract

Having established an easily reproducible, stable, technique for producing cardiogenic shock in dogs, and for applying the intraaortic balloon pump (IABP), a complementary study was carried out in six dogs that were treated for cardiogenic shock with the IABP associated with 8 micrograms/kg/min. of continuous intravenous dopamine. The results were compared with those obtained using only the IABP. It was found that dopamine associated with the IABP reduced the left ventricular end-diastolic pressure by 75.3% and increased the dP/dt and Vmax by 90% and 41.6% respectively. The heart rate rose from 134 (+/- 2.45) to 153.5 (+/- 14.13) beats per minute two hours after treatment. There were no changes in the mean aortic pressure and left ventricular systolic pressure, and diuresis was decreased. It is concluded that the IABP alone produces a significant decrease in the preload and increase in the afterload, but when associated with dopamine, no changes are observed in the afterload, but the preload falls considerably. Moreover, myocardial contractility is increased. Therefore dopamine and the IABP used together have synergic beneficial effects.

• Authors: F Malpartida, I Muguerza, D Martínez-Caro
• Journal: Archivos del Instituto de Cardiologia de Mexico (Arch Inst Cardiol Mex) 1976 May-Jun Vol. 46 Issue 3 Pg. 295-304 ISSN: 0020-3785 [Print] Mexico
• Vernacular Title: Efectos sinérgicos de la contrapulsación intraaórtica y la dopamina en el choque cardiogénico experimental con tórax cerrado.
• PMID: 1088853 (Publication Type: English Abstract, Journal Article)

Chemical References

• Dopamine

Topics

• Animals
• Combined Modality Therapy
• Dogs
• Dopamine (pharmacology, therapeutic use)
• Intra-Aortic Balloon Pumping
• Shock, Cardiogenic (therapy)