Effect of herbal medicine Saiko-keishi-to (TJ-10) on rat spontaneous chronic pancreatitis: comparison with other herbal medicines.

Abstract

BACKGROUND:

In an attempt to obtain evidence of the beneficial effects of TJ-10, we investigated the gene expression of PAP, an acute phase protein specific for pancreatitis in rat spontaneous chronic pancreatitis.

METHODS:

Four-wk-old male WBN/Kob rats were fed with MB-3 pellet diet containing herbal medicine. There were two administration groups for each drug: the prophylactic group administered from 4-12 wk, and the therapeutic group administered from 12-20 wk. Untreated control rats were fed with MB-3 alone. Histopathologic changes and PAP gene expressions were analyzed at 12 and 20 wk.

RESULTS:

In the prophylactic group, TJ-10-treated WBN/Kob rats showed no evidence of pancreatitis, and there was the amelioration of pancreatitis in the pancreata of the rats treated with other herbal medicines except TJ-24 at 12 wk. PAP mRNA was not expressed in the TJ-10-treated rats, and PAP gene expression was suppressed in rats treated with other drugs except TJ-107. In the therapeutic group, the amelioration of pancreatitis was seen only in TJ-10-treated rats, but PAP gene expression was significantly suppressed in the rats treated with all herbal medicines tested, compared with that in untreated control rats.

CONCLUSION:

An herbal medicine Saiko-keishi-to (TJ-10) delayed the onset of chronic pancreatitis in the WBN/Kob rat, and suppressed the pancreatitis-associated protein (PAP) gene expression more significantly than other herbal medicines.

• Authors: Y Motoo, S B Su, M J Xie, H Taga, N Sawabu
• Journal: International journal of pancreatology : official journal of the International Association of Pancreatology (Int J Pancreatol) Vol. 27 Issue 2 Pg. 123-9 (Apr 2000) ISSN: 0169-4197 [Print] United States
• PMID: 10862511 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acute-Phase Proteins
• Antigens, Neoplasm
• Biomarkers, Tumor
• Drugs, Chinese Herbal
• Lectins, C-Type
• Pancreatitis-Associated Proteins
• REG3A protein, human
• RNA, Messenger
• Reg3b protein, rat
• saiko-keishi-to

Topics

• Acute-Phase Proteins (genetics)
• Animals
• Antigens, Neoplasm
• Biomarkers, Tumor
• Chronic Disease
• Drugs, Chinese Herbal (therapeutic use)
• Gene Expression (drug effects)
• Lectins, C-Type
• Male
• Pancreatitis (drug therapy, pathology, prevention & control)
• Pancreatitis-Associated Proteins
• RNA, Messenger (metabolism)
• Rats
• Rats, Inbred Strains