Abstract | OBJECTIVE: To test the hypothesis that postmenopausal women with a history of eclampsia manifest a more high risk lipid profile than postmenopausal women with a history of normal pregnancy. SETTING: The Department of Obstetrics and Gynaecology, National University Hospital, Reykjavik, Iceland, and the Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA. PARTICIPANTS: Thirty Icelandic women with a history of eclampsia, aged between 50 and 67 years at the time of re-examination (cases) were individually matched for current age, and for age and parity at index pregnancy, to 30 unrelated Icelandic women with a history of normal pregnancy (controls). METHODS: RESULTS: Mean low density lipoprotein size was significantly smaller and apolipoprotein B concentration was higher in women with prior eclampsia. The percentage of cases receiving blood pressure medication (33%) was significantly greater than controls (6.7%). Thirteen cases had had hypertensive complications in at least one other pregnancy (recurrent subgroup); postmenopausally, these women displayed significantly increased diastolic blood pressures, smaller-sized low density lipoprotein, increased apolipoprotein B, decreased high density lipoprotein2 ( HDL2) cholesterol, and increased total cholesterol: HDL cholesterol ratio compared with their controls. Fourteen cases were normotensive in all other pregnancies (nonrecurrent); these showed no differences from their controls. CONCLUSIONS: Dyslipoproteinaemia is more prevalent among postmenopausal women with prior eclampsia, especially with recurrent hypertension in pregnancy, than in postmenopausal women with prior normal pregnancies.
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Authors | C A Hubel, S Snaedal, R B Ness, L A Weissfeld, R T Geirsson, J M Roberts, R Arngrímsson |
Journal | BJOG : an international journal of obstetrics and gynaecology
(BJOG)
Vol. 107
Issue 6
Pg. 776-84
(Jun 2000)
ISSN: 1470-0328 [Print] England |
PMID | 10847235
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Blood Glucose
- Insulin
- Lipids
- Lipoproteins, LDL
|
Topics |
- Aged
- Blood Glucose
(metabolism)
- Cardiovascular Diseases
(blood, complications)
- Eclampsia
(blood, complications)
- Female
- Humans
- Hypolipoproteinemias
(blood, complications)
- Insulin
(blood)
- Lipids
(blood)
- Lipoproteins, LDL
(blood)
- Middle Aged
- Postmenopause
(blood)
- Pregnancy
- Risk Factors
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