Peroxiredoxin I expression in oral cancer: a potential new tumor marker.

Abstract

This study investigates the applicability of the novel antioxidant protein, peroxiredoxin (Prx) I as a marker for tumor status in oral squamous cell carcinoma (SCC). Samples from 53 patients with SCC in the oral cavity were examined by immunohistochemistry. Correlations between the expression level of Prx I and proliferating cell nuclear antigen (PCNA), the clinical features of tumors, and their histopathological classifications were statistically analyzed. Cases exhibiting low Prx I expression level included significantly more with larger tumor mass cases (T-category, P=0.004), positive lymph node metastasis (N-category, P=0.015), advanced stage (P=0.002), and poorly differentiated cells (P=0.020). There was no significant difference between Prx I expression and the other indices.

• Authors: T Yanagawa, S Iwasa, T Ishii, K Tabuchi, H Yusa, K Onizawa, K Omura, H Harada, H Suzuki, H Yoshida
• Journal: Cancer letters (Cancer Lett) Vol. 156 Issue 1 Pg. 27-35 (Aug 01 2000) ISSN: 0304-3835 [Print] Ireland
• PMID: 10840156 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Proliferating Cell Nuclear Antigen
• Peroxidases
• Peroxiredoxins

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (analysis)
• Carcinoma, Squamous Cell (chemistry, mortality, pathology)
• Female
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Mouth Neoplasms (chemistry, mortality, pathology)
• Neoplasm Staging
• Peroxidases (analysis)
• Peroxiredoxins
• Proliferating Cell Nuclear Antigen (analysis)
• Survival Rate