Abstract | BACKGROUND: METHODS: Twenty-eight patients at Fletcher Allen Health Care and The Cleveland Clinic Foundation were treated for acute colonic pseudo-obstruction with neostigmine 2.5 mg IV over 3 minutes while being monitored with telemetry. Mechanical obstruction had been excluded. RESULTS: Complete clinical resolution of large bowel distention occurred in 26 of the 28 patients. Time to pass flatus varied from 30 seconds to 10 minutes after administration of neostigmine. No adverse effects or complications were noted. Of the two patients who did not resolve, one had a sigmoid cancer that required resection and one patient died from multiorgan failure. CONCLUSION:
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Authors | G T Trevisani, N H Hyman, J M Church |
Journal | Diseases of the colon and rectum
(Dis Colon Rectum)
Vol. 43
Issue 5
Pg. 599-603
(May 2000)
ISSN: 0012-3706 [Print] United States |
PMID | 10826417
(Publication Type: Journal Article)
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Chemical References |
- Parasympathomimetics
- Neostigmine
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Topics |
- Acute Disease
- Aged
- Aged, 80 and over
- Colonic Pseudo-Obstruction
(diagnosis, drug therapy, etiology)
- Female
- Humans
- Infusions, Intravenous
- Male
- Middle Aged
- Neostigmine
(administration & dosage, adverse effects)
- Parasympathomimetics
(administration & dosage, adverse effects)
- Treatment Outcome
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