Decreasing incidence of CNS AIDS-defining events associated with antiretroviral therapy.

Abstract

The authors enrolled 1,029 patients with CD4 counts </= 200/microL and no CNS AIDS-defining events (CNS-AIDS) between January 1993 and December 1998. The primary end point was the first appearance of CNS-AIDS. Three different periods and different antiretroviral regimens were considered. During the median follow-up of 329 days, 144 patients (9.5%) developed CNS-AIDS. The independent predictors were CD4 counts and therapy. All regimens decreased the risk of CNS-AIDS. Highly active antiretroviral therapy led to a 95% risk reduction in comparison with untreated patients.

• Authors: A d'Arminio Monforte, P G Duca, L Vago, M P Grassi, M Moroni
• Journal: Neurology (Neurology) Vol. 54 Issue 9 Pg. 1856-9 (May 09 2000) ISSN: 0028-3878 [Print] United States
• PMID: 10802799 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-HIV Agents

Topics

• AIDS Dementia Complex (diagnosis, drug therapy)
• Adult
• Anti-HIV Agents (adverse effects, therapeutic use)
• CD4 Lymphocyte Count
• Drug Therapy, Combination
• Female
• Follow-Up Studies
• HIV Seropositivity (diagnosis, drug therapy)
• Humans
• Male
• Risk Factors