Abstract |
The effect of subunit vaccination on the incidence and severity of primary and recurrent genital herpes was investigated in the female guinea pig model of herpes simplex virus (HSV) type 2 genital infection. After prophylactic immunization with zwitterionic detergent-solubilized HSV-1 glycoproteins formulated with alhydrogel or as immunostimulating complex particles, significant reductions in the incidence and severity of primary herpetic illness were observed in both vaccinated groups compared with immunization-naive controls. There was a significant reduction in the incidence of spontaneous herpetic recurrences after administration of HSV-1 antigens formulated as immunostimulatory complexes to guinea pigs in a prophylactic mode (P<.01). Increased levels of both postimmunization and postchallenge ELISA and neutralizing antibodies were significant correlates of protection against primary herpetic disease in a prophylactic scenario. However, no correlation was observed between elevated ELISA or neutralizing antibody levels and protection against recurrent disease following prophylactic or therapeutic administration of HSV-1 subunit vaccines.
|
Authors | J R Simms, A W Heath, R Jennings |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 181
Issue 4
Pg. 1240-8
(Apr 2000)
ISSN: 0022-1899 [Print] United States |
PMID | 10762560
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Adjuvants, Immunologic
- Antibodies, Viral
- Antigens, Viral
- ISCOMs
- Viral Vaccines
|
Topics |
- Adjuvants, Immunologic
- Animals
- Antibodies, Viral
(biosynthesis)
- Antigens, Viral
(immunology)
- Chlorocebus aethiops
- Disease Models, Animal
- Enzyme-Linked Immunosorbent Assay
- Female
- Guinea Pigs
- Herpes Genitalis
(prevention & control, therapy)
- Herpesvirus 1, Human
(immunology)
- Herpesvirus 2, Human
- ISCOMs
(immunology)
- Neutralization Tests
- Secondary Prevention
- Vero Cells
- Viral Vaccines
(immunology)
|