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In-vitro activity of arbekacin alone and in combination with vancomycin against gentamicin- and methicillin-resistant Staphylococcus aureus.

Abstract
In-vitro susceptibility studies were performed on 99 clinical Staphylococcus aureus isolates. A total of 68 of 73 methicillin-resistant S. aureus and 2 of 26 methicillin-susceptible S. aureus were gentamicin-resistant (gentamicin MIC range 16 to 1,024 microg/mL). All 70 gentamicin-resistant isolates contained the aac(6')-Ie-aph(2'')-Ia aminoglycoside resistance gene, and none possessed the aph(2'')-Ic or aph(2'')-Id aminoglycoside resistance genes. The arbekacin MIC for the 70 gentamicin-resistant isolates ranged from 0.25 to 4 microg/mL. The combination of arbekacin plus vancomycin produced synergistic killing against 12 of 13 gentamicin-resistant MRSA isolates. The combination of gentamicin plus vancomycin produced synergistic killing against 7 of the same 13 isolates. Arbekacin may prove useful when used in combination with vancomycin in treating infections caused by gentamicin-resistant MRSA.
AuthorsI You, R Kariyama, M J Zervos, H Kumon, J W Chow
JournalDiagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) Vol. 36 Issue 1 Pg. 37-41 (Jan 2000) ISSN: 0732-8893 [Print] United States
PMID10744365 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Aminoglycosides
  • Anti-Bacterial Agents
  • DNA, Bacterial
  • Gentamicins
  • Dibekacin
  • Vancomycin
  • arbekacin
Topics
  • Aminoglycosides
  • Anti-Bacterial Agents (administration & dosage, pharmacology)
  • Base Sequence
  • DNA, Bacterial
  • Dibekacin (administration & dosage, analogs & derivatives)
  • Drug Interactions
  • Drug Resistance, Multiple
  • Drug Therapy, Combination (pharmacology)
  • Gentamicins (pharmacology)
  • Humans
  • Methicillin Resistance
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Sensitivity and Specificity
  • Staphylococcus aureus (drug effects, isolation & purification)
  • Vancomycin (administration & dosage)

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