Suppression of food intake, body weight, and body fat by jejunal fatty acid infusions.

Abstract

Three experiments investigated effects of jejunal lipid infusions given on 4 or 21 consecutive days in adult, male Sprague-Dawley rats. In experiment 1, 7-h infusions of linoleic or oleic acid (0.2 ml/h for 7 h; total load = 11.5 kcal) on 4 consecutive days reduced total intake (ad libitum consumption of the liquid diet Boost, Mead Johnson, plus load) by approximately 15% and decreased weight gain compared with 4-day tests with saline administration. In experiment 2, linoleic acid at 0.1 ml/h for 7 h (5.7 kcal) was ineffective, whereas the same load delivered in 3.5 h produced effects similar in magnitude to those in the first experiment. In experiment 3, jejunal infusions of linoleic acid (0.2 ml/h for 7 h) on 21 consecutive days reduced mean total intake by 16%, body weight by 10%, and carcass fat by 48% compared with controls receiving saline. The net decrease in caloric intake may reflect the combined activation of pre- and postabsorptive mechanisms, and it suggests a possible treatment for obesity.

• Authors: J E Cox, W J Tyler, A Randich, G R Kelm, S S Bharaj, R J Jandacek, S T Meller
• Journal: American journal of physiology. Regulatory, integrative and comparative physiology (Am J Physiol Regul Integr Comp Physiol) Vol. 278 Issue 3 Pg. R604-10 (Mar 2000) ISSN: 0363-6119 [Print] United States
• PMID: 10712279 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Oleic Acid
• Linoleic Acid

Topics

• Adipose Tissue (drug effects, physiology)
• Animals
• Body Weight (drug effects)
• Eating (drug effects, physiology)
• Jejunum (drug effects, physiology)
• Linoleic Acid (administration & dosage)
• Male
• Oleic Acid (administration & dosage)
• Rats
• Rats, Sprague-Dawley