Fatty acid-depleted albumin induces the formation of echovirus A particles.

Abstract

Picornavirus infection requires virus uncoating, associated with the production of 135S "A" particles and 80S empty particles from 160S mature virions, to release the RNA genome into the cell cytoplasm. Normal albumin inhibits this process. We now show that when depleted of fatty acids, albumin induces the formation of echovirus A particles.

• Authors: T Ward, R M Powell, Y Chaudhry, J Meredith, J W Almond, W Kraus, B Nelsen-Salz, H J Eggers, D J Evans
• Journal: Journal of virology (J Virol) Vol. 74 Issue 7 Pg. 3410-2 (Apr 2000) ISSN: 0022-538X [Print] United States
• PMID: 10708459 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Albumins
• Fatty Acids
• RNA, Viral

Topics

• Albumins (chemistry, physiology)
• Enterovirus B, Human (genetics, physiology)
• Fatty Acids (chemistry)
• Genome, Viral
• RNA, Viral
• Virion