Abstract | PURPOSE: PATIENTS AND METHODS: RESULTS: The maximum Cho:NAA ratio ranged from 1.1 to 13.2 (median, 4.5); the Cho:NAA ratio in areas of normal-appearing brain tissue was less than 1.0. The maximum Cho:NAA ratio for each histologic subtype varied considerably; approximately equal numbers of patients within each tumor type had maximum Cho:NAA ratios above and below the median. Patients with a maximum Cho:NAA ratio greater than 4.5 had a median survival of 22 weeks, and all 13 patients died by 63 weeks. Patients with a Cho:NAA ratio less than or equal to 4.5 had a projected survival of more than 50% at 63 weeks. The difference was statistically significant (P =.0067, log-rank test). CONCLUSION:
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Authors | K E Warren, J A Frank, J L Black, R S Hill, J H Duyn, A A Aikin, B K Lewis, P C Adamson, F M Balis |
Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology
(J Clin Oncol)
Vol. 18
Issue 5
Pg. 1020-6
(Mar 2000)
ISSN: 0732-183X [Print] United States |
PMID | 10694552
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Protons
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Topics |
- Adolescent
- Adult
- Biomarkers, Tumor
(analysis)
- Brain Neoplasms
(diagnosis, mortality, pathology)
- Child
- Child, Preschool
- Humans
- Magnetic Resonance Spectroscopy
(methods)
- Neoplasm Recurrence, Local
- Pilot Projects
- Prognosis
- Protons
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