Abstract | OBJECTIVE: To determine whether Helicobacter pylori is an independent risk factor for bleeding peptic ulcer in users of non-steroidal anti-inflammatory drugs ( NSAIDs), including aspirin. DESIGN: A prospective matched case-control study. SETTING: Odense University Hospital, Denmark. SUBJECTS: 132 patients with a bleeding peptic ulcer (n=124) or haemorrhagic gastritis (n=8) at endoscopy who had taken an NSAID in the previous week and 136 controls who had taken NSAIDs without gastrointestinal complications. The controls were recruited from rheumatology and geriatric outpatient clinics. MEASUREMENTS: H pylori status assessed by serology and 13C-urea breath test and regarded as positive if either test was positive. Data on potential confounding factors including smoking and alcohol were collected by interview. MAIN RESULT: CONCLUSION:
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Authors | C J Hawkey |
Journal | Gut
(Gut)
Vol. 46
Issue 3
Pg. 310-1
(Mar 2000)
ISSN: 0017-5749 [Print] England |
PMID | 10673289
(Publication Type: Journal Article)
|
Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
|
Topics |
- Anti-Inflammatory Agents, Non-Steroidal
(adverse effects)
- Case-Control Studies
- Helicobacter Infections
(complications)
- Helicobacter pylori
- Humans
- Peptic Ulcer Hemorrhage
(etiology)
- Prospective Studies
- Risk Factors
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