Abstract | BACKGROUND/AIMS: METHODS: Rats received 90% partial hepatectomy (90% PH), and either lovastatin or vehicle alone daily. Survival and liver functions were assessed. RESULTS:
Lovastatin increased survival to 58% (vs. 6% in controls that received 90% PH without drug), decreased the peak ammonia level to 427 microM (vs. 846 microM in controls), increased the nadir of glucose to 88 mg/dl (vs. 57 mg/dl in controls), decreased the peak prothrombin time to 23 s (vs 29 s in controls), and decreased the peak activated partial thromboplastin time to 29 s (vs. 39 s in controls). The full survival and metabolic benefits were observed when lovastatin was started at 30 min after 90% PH, but lovastatin was less efficacious when started at later times. CONCLUSIONS:
Lovastatin increases the function of existing hepatocytes and might be used to improve liver function after extensive hepatic resection.
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Authors | S R Cai, K Motoyama, K J Shen, S C Kennedy, M W Flye, K P Ponder |
Journal | Journal of hepatology
(J Hepatol)
Vol. 32
Issue 1
Pg. 67-77
(Jan 2000)
ISSN: 0168-8278 [Print] Netherlands |
PMID | 10673069
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Blood Glucose
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Ammonia
- Lovastatin
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Topics |
- Ammonia
(blood)
- Animals
- Blood Coagulation Tests
- Blood Glucose
(drug effects)
- Cell Division
(drug effects)
- Hepatectomy
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(pharmacology)
- Liver
(pathology, physiopathology, surgery)
- Liver Failure
(mortality, pathology, physiopathology)
- Liver Function Tests
- Liver Regeneration
(drug effects, physiology)
- Lovastatin
(pharmacology)
- Organ Size
(drug effects)
- Rats
- Rats, Sprague-Dawley
- Survival Rate
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