Abstract | PURPOSE: The purpose of this work was to describe the changes of primary tumor and mediastinal lymph nodes on CT after neoadjuvant concurrent chemoradiotherapy and to correlate the CT findings with pathology. METHOD: Twenty-one consecutive patients [N2 disease (n = 19) or resectable T4 and N2 disease (n = 2)] with non-small cell lung cancer underwent neoadjuvant concurrent chemoradiotherapy. Changes of primary tumor and mediastinal nodes before and after the therapy were assessed using CT. The CT findings were correlated with pathologic findings. RESULTS: With neoadjuvant therapy, decrease in T stage was achieved in 9 of 21 (43%) patients on CT. On pathology, the remaining tumor consisted mostly of fibrosis and necrosis with little proportion of viable tumor cells (mean volume 17%, range 0-55%). Decrease in nodal stage was achieved in 14 of 21 (67%) patients on pathologic examination. Seven patients had cancer cells in mediastinal lymph nodes: in 6 of 9 (67%) patients with adenocarcinoma and 1 of 12 (8%) patients with squamous cell carcinoma (p = 0.016). CONCLUSION:
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Authors | K S Lee, Y M Shim, J Han, J Kim, Y C Ahn, K Park, K J Jung |
Journal | Journal of computer assisted tomography
(J Comput Assist Tomogr)
2000 Jan-Feb
Vol. 24
Issue 1
Pg. 35-40
ISSN: 0363-8715 [Print] United States |
PMID | 10667655
(Publication Type: Comparative Study, Journal Article)
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Topics |
- Adenocarcinoma
(diagnostic imaging, pathology, therapy)
- Adult
- Aged
- Biopsy
- Carcinoma, Non-Small-Cell Lung
(diagnostic imaging, pathology, therapy)
- Carcinoma, Squamous Cell
(diagnostic imaging, pathology, therapy)
- Chemotherapy, Adjuvant
- Female
- Humans
- Lung Neoplasms
(diagnostic imaging, pathology, therapy)
- Lymph Nodes
(diagnostic imaging, pathology)
- Lymphatic Metastasis
- Male
- Mediastinum
(diagnostic imaging)
- Middle Aged
- Neoplasm Staging
- Prognosis
- Radiotherapy, Adjuvant
- Retrospective Studies
- Tomography, X-Ray Computed
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