Abstract | RATIONALE: OBJECTIVE: METHODS: Male Wistar rats (n=12) were trained to discriminate between alprazolam (2.0 mg/kg, PO) and vehicle in an operant two-lever drug discrimination procedure under a tandem VI40"-FR10 schedule of reinforcement. Generalization and antagonism tests were carried out under 2 min extinction. RESULTS: In generalization tests, a number of benzodiazepines ( alprazolam, chlordiazepoxide, midazolam, lorazepam) and the barbiturate pentobarbital substituted completely, while zolpidem and abecarnil substituted partially for alprazolam. In contrast, no significant degree of generalization to the antidepressants imipramine and fluvoxamine and the putative antidepressants buspirone and flesinoxan was found. In antagonism studies alprazolam could be antagonized (almost) completely by flumazenil, partially by pentylenetetrazole, but not by methyl 6, 7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate ( DMCM), N-methyl-beta-carboline-3-carboxamide (FG-7142) and picrotoxin. CONCLUSIONS:
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Authors | J Gommans, T H Hijzen, R A Maes, B Olivier |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 148
Issue 2
Pg. 146-52
(Feb 2000)
ISSN: 0033-3158 [Print] Germany |
PMID | 10663429
(Publication Type: Journal Article)
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Chemical References |
- Anti-Anxiety Agents
- Antidepressive Agents, Tricyclic
- Convulsants
- GABA Agents
- Hypnotics and Sedatives
- Benzodiazepines
- Flumazenil
- Fluvoxamine
- Pentylenetetrazole
- Alprazolam
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Topics |
- Alprazolam
(agonists, antagonists & inhibitors, pharmacology)
- Animals
- Anti-Anxiety Agents
(agonists, antagonists & inhibitors, pharmacology)
- Antidepressive Agents, Tricyclic
(pharmacology)
- Behavior, Animal
(drug effects)
- Benzodiazepines
(pharmacology)
- Conditioning, Operant
(drug effects)
- Convulsants
(pharmacology)
- Discrimination, Psychological
(drug effects)
- Dose-Response Relationship, Drug
- Flumazenil
(pharmacology)
- Fluvoxamine
(pharmacology)
- GABA Agents
(pharmacology)
- Hypnotics and Sedatives
(pharmacology)
- Male
- Pentylenetetrazole
(pharmacology)
- Rats
- Rats, Wistar
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